Peroxisomal diseases

Several peroxisomal diseases are known in
man; the six most important are listed. All are
autosomal recessive hereditary disorders.
Patients with neonatal adrenoleukodystrophy
do not form sufficient amounts of plasmalogens
and cannot adquately degrade phytanic acid
and pipecolic acid. When cultured fibroblasts
frompatientswith genetically different types of
peroxisomal diseases are fused, the hybrid cells
form normal peroxisomes (cells with different
defects can correct each other).