According to estimates of the WHO (BullWorld
Health Org. 1983) about 275million persons are
heterozygotes for hemoglobin diseases worldwide.
Substantial numbers are due to the !-
thalassemias in Asia (over 60 million), $0-
thalassemia in Asia (30 million), HbE/!-thalassemia
in Asia (84 million), and sickle cell heterozygosity
in Africa (50million), India, the Caribbean,
and the USA (about 50 million). At least
200000 severely affected homozygotes are
born annually, about 50%, due to sickle cell anemia
and 50% to thalassemia
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